I think the need for pull incentives is redoubled by stories such as Allergan’s recent write-off of “$3.5 billion of total goodwill, including $622 million allocated to anti-infectives.” Ouch!Ĭomments are due to IACG by. As all of you know, we don’t get to have antibiotics in the pharmacy if we won’t reimburse them! For more, please read here (Ardal 2017), here (OHE 2017), here (DRIVE-AB 2017), and here (Davos 2018). The need for pull incentives (e.g., as discussed at Davos 2018 or in the UK’s recent commitment to delinked antibiotics) is implied in some of the comments and I hope that discussion expands over time. Most of the explanatory text focuses on push incentives which are of course welcome and making an outstanding difference (e.g., the > 30 companies in the past and present CARB-X portfolio). Of particular interest is the long-term strategy in point 5 of creating a One Health Global Leadership Group for Antimicrobial Resistance that would be “composed of a small group of current and former Heads of State, Ministers of Agriculture, Health and Environment, Heads of the Tripartite agencies, other UN and international agencies, Heads of Regional Banks and other prominent global leaders and eminent persons representing human, animal and plant health, as well as food production and the environment.” Global cooperation is so important and this is a great concept! This feels like it might the AMR-focused equivalent of the The Intergovernmental Panel on Climate Change ( IPCC), the United Nations body for assessing the science related to climate change.Īs to incentives for work on AMR, there’s a lot of call in points #2 and #4 for various types of investment: “The IACG calls upon public, private and philanthropic donors and other funders to increase investment and innovation in new antimicrobials – particularly antibiotics, diagnostics, vaccines, waste management tools, and safe and effective alternatives to antimicrobials – for human, terrestrial and aquatic animal and plant health.” These are all good themes and there’s a lot of important detail to be found in the primary paper. Strengthen accountability and global governance.The full text of the IACG announcement is below my signature but I’ll summarize for you by saying that at the very highest level the recommendations are: On the action side, IACG (the UN Interagency Coordination Group on Antimicrobial Resistance) has now released its draft recommendations ( link) with comments due by (and see below for discussion of an opportunity to comment in person in London on 7 Feb). As they state in their abstract, “The most plausible source … is bird and other wildlife guano… and … is concerning.” Deep sigh. In case you missed it, McCann et al. (Env Internat, “Understanding drivers of antibiotic resistance genes in High Arctic soil ecosystems,” link) have found NDM-1, one of our more famous recent resistance genes, in the Arctic. ![]() Apologies for inundating with updates … the last few days have been very data rich!
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